ChemInform Abstract: Hard and Soft Electrophilic and Nucleophilic Dissymmetry of α‐Oxoketenedithioacetals and p‐Nitro‐o‐phenylenediamine Exploited to Achieve the Regioselectivity in the Synthesis of 2‐Thiomethyl Ether Substituted Isomer of the Privileged Nucleus of 1,5‐Benzodiazepines over to Its 4‐Substituted Isomers.

Abstract

Hard and Soft Electrophilic and Nucleophilic Dissymmetry of α-Oxoketenedithioacetals and p-Nitro-o-phenylenediamine Exploited to Achieve the Regioselectivity in the Synthesis of 2-Thiomethyl Ether Substituted Isomer of the Privileged Nucleus of 1,5-Benzodiazepines over to Its 4-Substituted Isomers. -A regioselective way to synthesize 2-thiomethyl substituted isomers of 1,5-benzodiazepines is presented. -(CHAUDHARY*, P.; GUPTA, A.; DEVI, P.; KISHORE, D.;