ChemInform Abstract: Highly Effective and Enantioselective Michael Addition of 4‐Hydroxycoumarin to α,β‐Unsaturated Ketones Promoted by Simple Chiral Primary Amine Thiourea Bifunctional Catalysts.

Abstract

Highly Effective and Enantioselective Michael Addition of 4-Hydroxycoumarin to α,β-Unsaturated Ketones Promoted by Simple Chiral Primary Amine Thiourea Bifunctional Catalysts. -Among various thioureas tested, ATC is found to be the most efficient one. It is successfully applied to the title reaction to yield optically active coumaryl ketones including (S)-warfarin (III). -(MEI, R.-Q.; XU, X.-Y.; LI, Y.-C.; FU, J.-Y.; HUANG, Q.-C.; WANG*, L.-X.; Tetrahedron Lett. 52 (2011) 14, 1566-1568, http://dx.