ChemInform Abstract: Homoacyclovir Analogues of Unnatural Bases and Their Activity Against Hepatitis B Virus.

Abstract

Homoacyclovir Analogues of Unnatural Bases and Their Activity Against Hepatitis B Virus. -Seven compounds of type (V) are tested for their activities against hepatitis B virus. Three of them, viz. (V), show high inhibition activity and low cytotoxicity. -(EL ASHRY, E. S. H.; ABDEL-RAHMAN, A. A.-H.; RASHED, N.; RASHEED, H. A.; Pharmazie 54 (1999) 12, 893-897; Dep. Chem., Fac. Sci., Alexandria Univ., Alexandria 21321, Egypt; EN)

Synthesis of Quinoxaline Azido and Amino Reverse Ribofuranoside and TheirO-Regioisomers

“…[6,7] The pharmacological applications of quinoxalines are reported as angiotension II receptor antagonists, [8] N -methyl-D-aspartate (NMDA) antagonists, [9] anti-inflammatory, [10] antidepressanttranquilizing, [11,12] antitumor agents [13,14] as well as agents against hepatitis B virus (HBV). [15] Quinoxaline derivatives have been shown to block selectively EGFR kinase. AG 1295 (Figure 1) reverses the transformed phenotype of Ibrahim.…”

Three-Step Telescoped Synthesis of Monosubstituted Vicinal Diamines from Aldehydes

“…3 Also, quinoxalines and piperazines have interesting medical properties. For instance, quinoxaline derivatives display anticancer, 4 antiviral, 5 antibacterial, 6 anti-inflammatory, 7 and antibiotic 8 activities. A piperazine moiety is considered a “privileged scaffold” in medicinal chemistry 9 and is present in many biologically active molecules.…”

Highly Atom-Economic, Catalyst-Free, and Solvent-Free Synthesis of Phthalazinones

“…Nitrogen-containing heterocycles are core segments in a broad range of active compounds found frequently in pharmaceutical drugs, agrochemicals, and functional materials. − Among these, phthalazinones are a group of condensed heterocycles having significant biological activities which show great potential in the treatment of various pathological processes including diabetes, , hepatitis B, vascular hypertension, , asthma, , and arrhythmia . Azelastine is a well-known antiallergic and antihistaminic drug with $0.24 billion in sales in 2008 , as a phthalazinone derivative.…”