ChemInform Abstract: Hybrid Antioxidants

Abstract

Organic chemistry Z 0200Hybrid Antioxidants -[100 refs.]. -(BURLAKOVA, E. B.; MOLOCHKINA, E. M.; NIKIFOROV, G. A.; Oxid.

Dependence of Phenol Toxicity on Kind and Position of Substitutes

“…It was noted that introduction of acetyl group to N-position of symmetrical 4-aminomethyl-2,6-di-tertbutylphenol has decreased the substance toxicity according to the value LD 50 6 times (Table 1, samples 3,13).…”

“…The low level quantity of lipids peroxide in normal tissues is explained by well-balanced processes of peroxide formation and expenses. Breaking this balance results in changing the antioxidant status of the organism and may be the cause of some pathologies [2,3]. In some studies it was established that AO therapy was necessary for treating many diseases, and free radical processes do play a certain role.…”

Dissociation energies of N-H bonds in aromatic amines (review)

“…Hybrid antioxidants are finding progressively increasing use as medicaments for the treatment of various diseases [41]. The mecha nism of their inhibitory action is more complex than that of monofunctional antioxidants, since both func tional groups are involved in the termination of oxida tion chains and one molecule of such an inhibitor gives rise to two different intermediate radicals, the aminyl and phenoxyl radicals, to take part in radical reactions.…”