ChemInform Abstract: Improved Synthesis of β‐Trimethylsilyloxy Nitriles in a Solvent‐ Free Reaction under Classical Heating or Microwave Activation.

Abstract

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The Recycling of Substandard Rocket Fuel N,N-Dimethylhydrazine via the Involvement of Its Hydrazones Derived from Glyoxal, Acrolein, Metacrolein, Crotonaldehyde, and Formaldehyde in Organic Synthesis

“…Furthermore, the phenyl hydrazone derivative 68a undergoes cyclization via methyl alcohol elimination under MWI catalysis, resulting in the formation of N-phenylpyridazine 69a. Interesting chemical transformations (Figure 12) are presented in publication [62], which explores solvent-free and pipyridine-catalyzed reactions under microwave irradiation (MWI), an effective method for dry organic syntheses [63][64][65][66][67][68][69][70][71][72]. Phenylhydrazone (HGa) and dimethylhydrazone (HGb) react with acetoacetic ether in a 1:1 ratio to form conjugated compounds 68a and 68b.…”

Nucleophilic Addition of α-(Dimethylsilyl)nitriles to Aldehydes and Ketones

“…Therefore, recent attention has been focused on Lewis base-promoted addition of α-(trimethylsilyl)nitriles (α-TMS-nitriles), stable equivalents of α-cyano carbanions. Several methods for this silicon-mediated carbonyl addition have been reported. ,− However, these studies mostly deal with the reaction of TMS-acetonitrile (Me 3 SiCH 2 CN). There are only a few examples for carbonyl addition of sterically congested α-TMS-nitriles .…”