ChemInform Abstract: Interaction of 2‐Piperazinobenzaldehyde with Cyanoacet(thio)amide: Stereoselective Cyclization by the “tert‐Amino Effect” Mechanism.

Abstract

Pyrazine derivatives R 0550Interaction of 2-Piperazinobenzaldehyde with Cyanoacet(thio)amide: Stereoselective Cyclization by the "tert-Amino Effect" Mechanism. -Under conditions A the thioamide (IIIa) cyclizes to give product (IV) whereas the amide (IIIb) does not cyclize at all. -(GLUKHAREV, T. V.; KLIMOVA, E. P.; PLATONOVA, A. Y.; MORZHERIN*, Y. Y.; Chem. Heterocycl. Compd. (N. Y.) 44 (2008) 6, 759-761; Ural State Tech. Univ., Ekaterinburg 620002, Russia; Eng.) -M. Bohle 24-168