ChemInform Abstract: Ionic Liquids Synthesis ‐ Methodologies

Ferraz, Ricardo; Prudêncio, Cristina; Vieira, Mónica; Fernandes, Rita; Noronha, João Paulo; Petrovski, Željko

doi:10.1002/chin.201538264

Cited by 4 publications

(6 citation statements)

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“…In general, the conventional and widely used IL synthetic methods are usually seen as not eco‐friendly because they involve the use of large amounts of solvent and metathesis reactions, generally leading to the formation of undesired inorganic salts as impurities . In the case of metathesis reactions, additional purification methods and further precipitation of inorganic salts are always required . Alternative methods based on solution neutralization are also applied and used as possible greener strategies .…”

Section: Methodsmentioning

confidence: 99%

MechanoAPI‐ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis

et al. 2017

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An alternative, efficient, and green synthetic strategy for the preparation of pharmaceutical ionic liquids using mechanochemistry (MechanoAPI-ILs) is reported. Six new API-ILs based on gabapentin and l-glutamic acid were successfully synthesized and characterized, demonstrating that mechanochemistry is a very promising synthetic strategy. Results compare both the new and the classical approach and clearly show the advantages of the new method. This new technique is faster, solvent free, reproducible, selective, and leads to higher yields.

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Section: Methodsmentioning

confidence: 99%

MechanoAPI‐ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis

et al. 2017

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“…zabývali potenciálními aplikacemi membrán a IL pro průmyslové využití 42 . IL se užívají napříč téměř všemi přírodovědnými obory, objevují se multidisciplinární studie z oblasti obecné chemie, materiálové chemie, chemického inženýrství a v neposlední řadě také v oblasti životního prostředí 43 .…”

Section: Iontové Kapaliny Jako Další Složka MMMunclassified

“…alkylhalogenidů (nejčastěji jodidů), síranů nebo trifluormethansulfonátů, čímž pak vznikají odpovídající alkylamoniové halogenidy, sírany nebo triflátové IL (cit. 43 ). Za zmínku stojí, že syntéza IL není omezena pouze na kombinaci jednoho páru aniont/kationt.…”

Section: Iontové Kapaliny Jako Další Složka MMMunclassified

Mixed Matrix Membranes for Carbon Dioxide Capture

Hamalová

Kolská

2022

Chem. Listy

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Mixed-matrix membranes, MMM, have been a very popular research topic for many scientists in many fields during the last few years. This work provides an overview of general properties, interesting structural components, potential applications, as well as pitfalls and drawbacks in the preparation of membranes of this type. MMM, especially when combined with ionic liquids, IL, and/or organometallic frames, MOF, represent one of the best and very promising options for industrial applications, specifically for the capturing and separation of CO2. As a result, the properties of these two fillers (IL and/or MOF) can enable us to prepare membranes with a higher separation and permeability efficiency, chemical and mechanical resistance, and thermal stability. Unfortunately, the toxicity and stability of the individual components of the membranes and the resulting mixed matrix membranes have not yet been investigated in detail and further research is needed. One of the main drawbacks is a very high cost of the production of the individual parts and the subsequent assembly of these composite membranes. This is the reason why we still do not see these MMM being used widely in industry.

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“…Loratadine and selected counter-ion were mixed in the ratio mentioned in table 1 by continuous stirring in ethanol in a water bath for 10 min at 70-80 °C [20]. The resultant IL salt was collected by evaporating solvent at room temperature in airtight vials and stored at ambient condition till further characterization and evaluation.…”

Section: Preparation Of Il Saltsmentioning

confidence: 99%

Synthesis and Evaluation of Taste-Masked Ionic Liquid Salts of Loratadine

Gondane¹,

Sapkal²,

Jaiswal³

2020

Int J Pharm Pharm Sci

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Objective: To synthesize and evaluate taste-masked ionic liquid (IL) salts of loratadine. Methods: In the present work, pharmaceutically active IL salts of loratadine using selected counter-ions were synthesized. The synthesized IL salts were characterized using melting point, Ultraviolet (UV) spectroscopy, Fourier Transform Infra-Red (FTIR) spectroscopy, Differential Scanning Calorimetry (DSC), and X-ray Diffraction (XRD). These salts were also evaluated for solubility, dissolution, and palatability studies. Results: All synthesized IL salts of loratadine exhibited melting points below 100 °C. UV spectral data and FTIR data confirmed the formation of new salt forms with selected counter-ions. The absence of sharp melting point peaks during DSC studies revealed the amorphous nature of new salt forms. During XRD studies, loratadine-indomethacin IL salt yields completely amorphous compound while the intensity of characteristic peaks of loratadine was found to be reduced with other counter-ions. Solubility studies revealed that the solubility of loratadine is reduced from 35.85 mg/ml to 3.63 mg/ml, 15.39 mg/ml, 5.31 mg/ml, and 3.71 mg/ml in case of IL-1, IL-2, IL-3, and IL-4, respectively. Dissolution studies further confirmed this finding. Except for oleate, all the IL salts were found to be palatable by subjects with the score ranging from 2.5 to 2.8, which is the standard range for palatability. Conclusion: Results obtained in the present work indicated that IL salts of loratadine can be synthesized successfully using selected counter-ions. This approach can be used to mask the bitter taste of pure loratadine and thus can be used for the development of drug products intended for children.

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ChemInform Abstract: Ionic Liquids Synthesis ‐ Methodologies

Cited by 4 publications

References 0 publications

MechanoAPI‐ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis

MechanoAPI‐ILs: Pharmaceutical Ionic Liquids Obtained through Mechanochemical Synthesis

Mixed Matrix Membranes for Carbon Dioxide Capture

Synthesis and Evaluation of Taste-Masked Ionic Liquid Salts of Loratadine

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