ChemInform Abstract: Iron‐Catalyzed N‐Arylations of Amides.

Abstract

2008 N-Arylation O 0268Iron-Catalyzed N-Arylations of Amides. -A variety of aromatic and aliphatic amides is arylated with aromatic and heteroaromatic iodides using FeCl 3 /DMEDA as catalysts. An intramolecular version affords oxindole (Va) or quinolinone (Vb). -(CORREA, A.; ELMORE, S.; BOLM*, C.; Chem. Eur.

Impact of Deactivation Phenomena on Kinetics of the C–N Coupling Reaction over Supported Cu2O Catalysts in Continuous-Flow Conditions

“…Palladium is an expensive precious metal whose price abruptly rises (four times in the past decade) as a result of (i) near-depletion of natural reserves/stockpiles and (ii) high demand in the automotive industry to partially replace Pt in catalytic converters, together with a relatively low recovery degree (∼50%) from used catalytic converters. 6 All these drawbacks motivate the growing interest to replace critical materials such as Pd in C−N coupling catalysts with nonprecious metals like Fe, 7,8 Ni, 9 or Cu 10−13 or bimetallic systems such as Fe−Cu 14,15 and Cu−Ni. 16 On the other side, copper-catalyzed C−N coupling processes have been known for a long time, as Ullman condensation and Goldberg-modified Ullman condensation reactions; 10 however, the harsh reaction conditions limited their synthetic use.…”