Four new (1 – 4) and one known (5) acylated iridoid glycosides were isolated from the aerial parts of Veronicastrum sibiricum (L.) Pennell. The chemical structures of the isolated compounds were determined to be 3″,4″‐dicinnamoyl‐6‐O‐rhamnopyranosyl‐10‐O‐bergaptol‐5,7‐bisdeoxycynanchoside (1), 3″,4″‐dicinnamoyl‐6‐O‐rhamnopyranosylpaulownioside (2), 2″,4″‐dicinnamoyl‐6‐O‐rhamnopyranosylcatalpol (3), 3″,4″‐dicinnamoyl‐6‐O‐rhamnopyranosylaucubin (4), and 3″,4″‐dicinnamoyl‐6‐O‐rhamnopyranosylcatalpol (5) using spectroscopic techniques. Among these compounds, compound 5 increased antioxidant response element (ARE) luciferase activity.