ChemInform Abstract: Isoquinoline Derivatives. Part 28. Synthesis and Biological Properties of N‐Substituted 6,7‐Dimethoxy‐4‐spiroisoquinoline Derivatives.

Abstract

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Synthesis of novel 1,2-functionally-substituted 6,7-dimethoxy-4-spirocyclo-pentanetetrahydroisoquinolines

“…The synthesis of isoquinolines containing methyl substituents in the one position and spiro rings in a quaternary position has been reported previously [4,5]. The aim of this work was to preserve the spiro ring in the tetrahydroisoquinoline structure but to have functional groups like carbethoxy, amido, or hydroxymethyl in position one in order to prepare novel derivatives.…”