ChemInform Abstract: KINETICS OF OXIDATION OF ANILINE AND SUBSTITUTED ANILINES BY PERIODATE

Arylamine N-oxidation by the microsomal fraction of germinating pea seedlings (Pisum sativum)

“…The two arylamine substrates that were not oxidized by the microsomal system are extremes with respect to the electronic properties of arylamines. The amine group of 4-nitroaniline is a much weaker base than most arylamines (Rao et al, 1979) and has a substantially reduced electron density on the amine nitrogen relative to that of the other arylamines in Table I (Loew et al, 1979). These properties of 4-nitroaniline could explain the failure of the microsomal enzyme to effect N-oxidation.…”