ChemInform Abstract: Klebsiella pneumoniae (NBRC 3319) Mediated Asymmetric Reduction of α‐Substituted β‐Oxo Esters and Its Application to the Enantioselective Synthesis of Small‐Ring Carbocycle Derivatives.

Abstract

Klebsiella pneumoniae (NBRC 3319) Mediated Asymmetric Reduction of α-Substituted β-Oxo Esters and Its Application to the Enantioselective Synthesis of Small-Ring Carbocycle Derivatives. -Ketoreductases from Klebsiella pneumoniae selectively reduce 2-substituted 3-oxobutyrates (I) to syn-β-hydroxy esters (II) with remarkable stereocontrol. These esters are effective precursors of functionalized cyclopentane and cyclohexane frameworks such as (III) and (IV). -(BHUNIYA, R.; MAHAPATRA, T.; NANDA*, S.; Eur.