ChemInform Abstract: Large‐Scale Synthesis of New Pyranoid Building Blocks Based on Aldolase‐Catalyzed Carbon—Carbon Bond Formation.

Abstract

Formation. -The α,β-unsaturated δ-lactone (I) is subjected to the diastereoselective reaction with various S-, N-, O-and C-nucleophiles. Further transformations of building blocks (IIIa) and (IIIc) are demonstrated. -(WOLBERG*, M.; DASSEN, B. H. N.; SCHUERMANN, M.; JENNEWEIN, S.; WUBBOLTS, M. G.; SCHOEMAKER, H. E.; MINK, D.; Adv. Synth. Catal. 350 (2008) 11-12, 1751-1759; DSM Pharma Chem. Regensburg, D-93055 Regensburg, Germany; Eng.) -Y. Steudel 52-139