ChemInform Abstract: Mass Spectra of Some 1,3,4‐Thiadiazole Derivatives.

Abstract

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Design and Synthesis of α,β-Epoxyketones as New Anticancer Agents

“…20,21,24 The yields were obviously higher than that of traditional methods. 25 The syntheses of compounds 2 were carried out according to reported procedure, 13,14 and all of the compounds 2 had good yields (85%-93%). The title compounds 4 were obtained by Darzens condensation reactions.…”

“…[7][8][9] Besides epoxides, thiochromanones had been reported to possess important biological activities such as antifungal activity, 10 anti-inflammatory activities, 11 anticancer activity. 12 For example, 3-bromo-4-thiochromanone derivatives, 13,14 3-benzylienethiochromanone derivatives, 15,16 the Mannich base of thiochromanone derivatives, 17,18 3-halomethylene-thiochromanone derivatives, 19,20 2,3,3a,4-tetrahydrothiochromeno[4,3-c]-pyrazole derivatives 21 and 6H-thiochromeno-[4,3-b]-quinoline derivatives 22 etc. had been synthesized and reported to have high antifungal activities.…”

Synthesis and Biological Evaluation of 5-Formyl-6-arylimidazo(2,1-b)-1,3,4-thiadiazole-2-N-(dimethylaminomethino)sulfonamides as Antitumor Agents

“…The 2-sulfonamide group on interaction with dimethyl formamide, which was used as a reagent and reaction medium, was converted to the 2-N-(dimethylaminomethino)sulfonamide group. [4], phenacyl bromide [5], p-bromophenacylbromide [6], p-chlorophenacyl bromide [7], p-nitrophenacyl bromide [8], 3-bromo acetyl coumarin [9], 5-(p-nitrophenyl)-2-bromoacetyl furan [10], p-phenyl phenacyl bromide [6] were prepared according to the literature methods cited and various phenacyl bromides were obtained from bromination of corresponding acetophenones using anhydrous aluminium chloride as catalyst.…”

“…In view of the above and in continuation of our search for novel biologically active molecules [3, Compounds 1−7 analysed correctly for C,H,N with ± 0.40 % margin. 5-Bromo-6-Phenyl/ethylacetateimidazo (2,1-b)-1,3,4thiadiazole-2-sulfonamides (8 and 9) were prepared as per literature method [4].…”