ChemInform Abstract: METAL COMPLEXES WITH BIOLOGICALLY IMPORTANT LIGANDS. XXXIV. ALLYLPALLADIUM(II) AND TRIPHENYLPHOSPHINEGOLD(I) COMPLEXES WITH NUCLEOBASES AND NUCLEOSIDES

Anti-inflammatory Active Gold(I) Complexes Involving 6-Substituted-Purine Derivatives

“…These results indicate that the 6-benzylaminopurine derivatives coordinate through the N9 atoms and PPh 3 molecule coordinates to the central gold(I) atom through the phosphorus atom. The anticipated N9-coordination of the purine moiety to the Au(I) atom within the structure of 1 – 8 was reported for several gold(I) complexes, such as [Au(ade)PPh 3 ] and [Au(ade)PEt 3 ], where the deprotonated form of adenine (ade) coordinates to the central atom via the N9 atom of the purine moiety, as determined by the X-ray crystallographic study.…”

Regulating Transition Metal Catalysis Through Interference by Short RNAs

“…Interestingly, the potential for interstrand binding of Au(I) to dsDNA was originally proposed over three decades ago by Blank and Dabrowiak 34 . Spectroscopic experiments support the binding of Au(III) and Au(I) to the N7 of guanine and also support the formation of a dimeric Au(II) complex between two cytosine nucleosides 35,36,37,38 . Despite these theoretical predictions and experimental studies, the formation of a Au(I)-MMBP has not yet been reported.…”

“…Additionally, in bioactive Au(I) complexes, interactions between the gold center and DNA have been implicated as modes of action towards disease treatment 32,33 . Interestingly, the potential for interstrand binding of Au(I) to dsDNA was originally proposed over three decades ago by Blank of guanine and also support the formation of a dimeric Au(II) complex between two cytosine nucleosides 35,36,37,38 . Despite these theoretical predictions and experimental studies, the formation of a Au(I)-MMBP has not yet been reported.…”