ChemInform Abstract: Metal‐Free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones.

Abstract

Metal-Free Trifluoromethylation of Aromatic and Heteroaromatic Aldehydes and Ketones. -A convenient one-pot process is developed for converting aldehydes and ketones to trifluoroalkylated arenes and hetarenes. The method involves the use of stable R 3P + CF2COOas reagents and subsequent decarboxylative fluorination with Bu 4F. -(QIAO, Y.; SI, T.; YANG, M.-H.; ALTMAN*, R. A.; J. Org. Chem. 79 (2014) 15, 7122-7131, http://dx.doi.org/10.1021/jo501289v ; Dep. Med. Chem., Univ. Kans., Lawrence, KS 66045, USA; Eng.) -Mais 05-083