ChemInform Abstract: METAL SALT‐CATALYZED CARBENOIDS. XV. THE SYNTHETIC AND STRUCTURAL ASPECTS OF COPPER SALT‐CATALYZED ADDITIONS OF BIS(METHOXYCARBONYL)CARBENE TO OLEFINS

Wulfman, D. S.; Mcgibboney, Bradford G.; Steffen, E K; Thinh, Nguyen Van Thinh Nguyen Van; McDaniel, Robert S.; Peace, B. W.

doi:10.1002/chin.197636120

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“…The total carbohydrate, uronic acid, and protein contents were determined using phenol‐sulfuric acid (Dubois, Gilles, Hamilton, Rebers, & Smith, ) m‐hydroxydiphenyl, and Bradford methods (Bradford, ) with the standards of glucose, glucuronic acid, and bovine serum albumin (BSA) (Wulfman et al, ), respectively. Sugars components were analyzed by PMP pre‐column derivatization, which were then detected by HPLC (Shimadzu, Japan) with a C‐18 column (Shimadzu, Japan).The molecular weight analysis was used HPLC‐GPC method.…”

Section: Methodsmentioning

confidence: 99%

A novel oligosaccharide isolated fromHericium erinaceusand its protection against LPS‐induced Caco‐2 cells via the TLR4/NF‐κB pathway

Wang

Zhang

et al. 2020

J Food Biochem

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A novel oligosaccharide showed that protection against LPS‐induced Caco‐2 cells was purified from the mycelium of Hericium erinaceus (HE). WEP‐1 is mainly composed of neutral monosaccharides with molecular weight of 4,010 Da and of mannose, glucose, and galactose in a molar ratio of 1.2:16.9:1. The structure of WEP‐1 includes α‐D‐Glc (1 → 3) and β‐D‐Gal (1 → 3) as the backbone with β‐D‐Glc (1 → 3) as branches attached to the C‐4 position and β‐D‐Man as a terminal residue. The oligosaccharide reduced acetic acid‐induced colonic mucosa injury in rats. It also showed significant protection against LPS‐induced Caco‐2 cells via the TLR4/NF‐κB pathway. Practical applications In the study, the oligosaccharide from HE has the potential to be developed into functional foods or medicines for the treatment of intestinal diseases. The protection against LPS‐induced Caco‐2 cells via the TLR4/NF‐κB pathway may be a key target for the pharmacological activity of HE.

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Section: Methodsmentioning

confidence: 99%