ChemInform Abstract: Multifunctional Nanoparticles: Recent Progress in Cancer Therapeutics

Raju, G. Seeta Rama; Benton, Leah; Pavitra, E.; Yu, Jae Su

doi:10.1002/chin.201540248

Cited by 3 publications

(4 citation statements)

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“…Clinical use of nanoparticles has demonstrated improved efficacy and reduced adverse effects through adjustment of the systemic biodistribution of drugs, allowing higher doses of therapeutic agents to reach tumor sites. For example, the FDA-approved albumin-bound PTX drug Abraxane showed superior overall response rates and fewer adverse events than generic PTX in NSCLC patients [131].…”

Section: Nddss In Targeted Lung Cancer Therapymentioning

confidence: 99%

Physiologically driven nanodrug delivery system for targeted lung cancer treatment

Zhang,

Li,

Liu

et al. 2024

Exploration of Medicine

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Lung cancer remains a leading cause of cancer-related deaths globally, and a significant number of patients are ineligible for surgery, while chemoradiotherapy often shows limited efficacy, a systemic distribution, a low drug concentration at tumor sites, severe side effects, and the emergence of drug resistance. In this context, a nanodrug delivery system (NDDS) has emerged as a promising approach for lung cancer treatment, offering distinct advantages such as targeted delivery, responsiveness to the tumor microenvironment, site-specific release, and enhanced induction of apoptosis in cancer cells, ultimately leading to tumor growth inhibition or even elimination. This review aims to provide an overview of the physiological characteristics of lung cancer, highlight the limitations of conventional treatment methods, and extensively examine recent significant advancements in NDDS utilized for lung cancer therapy. The findings from this review lay the foundation for further development and optimization of NDDSs in the treatment of lung cancer.

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Section: Nddss In Targeted Lung Cancer Therapymentioning

confidence: 99%

Physiologically driven nanodrug delivery system for targeted lung cancer treatment

Zhang,

Li,

Liu

et al. 2024

Exploration of Medicine

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“…Furthermore, they must be able to target only the tumor cells without deteriorating surrounding healthy cells and need to release the load as soon as they reach the target site. All these features can be affected by the physicochemical properties of the nanoparticles employed as drug delivery vectors (Figure 4) [43,44]. The nanoparticles' size distribution has a major effect on their performance in cancer therapies.…”

Section: General Requirements For Nanoparticles In Drug Deliverymentioning

confidence: 99%

“…The nanoparticles' size distribution has a major effect on their performance in cancer therapies. Due to the tumor's leaky vasculature, the size of nanoparticles can be adapted to be small enough to penetrate the tumor and big enough to prevent extravasation from normal blood vessels, preventing agglomeration in other parts of the body [44]. Nevertheless, different organs have different size uptake specifications.…”

Section: General Requirements For Nanoparticles In Drug Deliverymentioning

confidence: 99%

Application of Nanoparticles in Cancer Treatment: A Concise Review

Sell,

Lopes,

Escudeiro

et al. 2023

Nanomaterials

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Timely diagnosis and appropriate antitumoral treatments remain of utmost importance, since cancer remains a leading cause of death worldwide. Within this context, nanotechnology offers specific benefits in terms of cancer therapy by reducing its adverse effects and guiding drugs to selectively target cancer cells. In this comprehensive review, we have summarized the most relevant novel outcomes in the range of 2010–2023, covering the design and application of nanosystems for cancer therapy. We have established the general requirements for nanoparticles to be used in drug delivery and strategies for their uptake in tumor microenvironment and vasculature, including the reticuloendothelial system uptake and surface functionalization with protein corona. After a brief review of the classes of nanovectors, we have covered different classes of nanoparticles used in cancer therapies. First, the advances in the encapsulation of drugs (such as paclitaxel and fisetin) into nanoliposomes and nanoemulsions are described, as well as their relevance in current clinical trials. Then, polymeric nanoparticles are presented, namely the ones comprising poly lactic-co-glycolic acid, polyethylene glycol (and PEG dilemma) and dendrimers. The relevance of quantum dots in bioimaging is also covered, namely the systems with zinc sulfide and indium phosphide. Afterwards, we have reviewed gold nanoparticles (spheres and anisotropic) and their application in plasmon-induced photothermal therapy. The clinical relevance of iron oxide nanoparticles, such as magnetite and maghemite, has been analyzed in different fields, namely for magnetic resonance imaging, immunotherapy, hyperthermia, and drug delivery. Lastly, we have covered the recent advances in the systems using carbon nanomaterials, namely graphene oxide, carbon nanotubes, fullerenes, and carbon dots. Finally, we have compared the strategies of passive and active targeting of nanoparticles and their relevance in cancer theranostics. This review aims to be a (nano)mark on the ongoing journey towards realizing the remarkable potential of different nanoparticles in the realm of cancer therapeutics.

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“…Together, the different qualities of NPs determine how well they can treat cancer. [13][14][15] In this regard, the accumulation of nanoparticles in cancer cells is determined by passive diffusion or convection through the leaky, hyperpermeable vasculature tumour. The high surface of nanoparticles, results in increased cellular uptake.…”

Section: Introductionmentioning

confidence: 99%

Harnessing Nanotechnology for Optimized Herbal Cancer Treatment: A Comprehensive Review of Nanoscale Drug Delivery Systems

Sadat Razavi,

Ahmadi,

Ebrahimnejad

et al. 2024

Pharm Sci

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Cancer is widely recognized as the second leading cause of death on a global scale. In recent years, nanotechnology has emerged as a promising strategy in the field of cancer therapy. Nanoscale drug delivery systems, a category of innovative technologies, harness the potential of various nanoparticles and nanomaterials to efficiently transport chemotherapeutic drugs, revolutionizing cancer treatment. The use of natural products has shown substantial promise in both the prevention and therapy of cancer. Herbal medicines, in particular, have gained widespread use due to their inherent therapeutic advantages and notably fewer adverse effects compared to modern drugs. However, their hydrophobic nature has presented a challenge, limiting their bioavailability and therapeutic efficacy. To overcome these limitations, researchers have developed nanocarriers tailored for the delivery of therapeutic agents to specific target cells. The combination of nanocarriers with herbal remedies results in improved bioavailability, enhanced pharmacological activity, and increased stability, all while minimizing systemic toxicity in cancer treatment. This review provides a comprehensive discussion of novel nanocarriers that find application in cancer treatment, with a specific focus on herbal medicine. The amalgamation of these innovative approaches offers promising prospects for the future of cancer therapy.

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ChemInform Abstract: Multifunctional Nanoparticles: Recent Progress in Cancer Therapeutics

Abstract: Review: 102 refs.

Cited by 3 publications

References 1 publication

Physiologically driven nanodrug delivery system for targeted lung cancer treatment

Physiologically driven nanodrug delivery system for targeted lung cancer treatment

Application of Nanoparticles in Cancer Treatment: A Concise Review

Harnessing Nanotechnology for Optimized Herbal Cancer Treatment: A Comprehensive Review of Nanoscale Drug Delivery Systems

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