ChemInform Abstract: Mutagenic and Antimutagenic Effects of 5‐Substituted 2′‐Deoxyuridines Depending on the Nature of the 5‐Substituent.

Westendorf, Johannes; Schaefer, Amber; Boldt, Jeffrey L.; Clercq, E. De; Marquardt, Hans

doi:10.1002/chin.198921302

Cited by 2 publications

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“…Knowledge of the metabolic pathway of CEDU and identification of its new metabolite (metabolite II) may increase our understanding of the mutagenic (20) and carcinogenic (E. De Clercq and H. Sobis, unpublished data) potential of the parent compound. It would seem imperative to examine whether metabolite II may be responsible for these serious side effects of CEDU.…”

Section: Discussionmentioning

confidence: 99%

Metabolism of anti-herpes agent 5-(2-chloroethyl)-2′-deoxyuridine in mice and rats

Szlnai

Veres

Ganzler

et al. 1991

European Journal of Drug Metabolism and Pharmacokinetics

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The enzymatic splitting and metabolic elimination of anti-viral agent 5-(2-chloroethyl)-2'-deoxyuridine [CEDU] have been studied. For elucidation of structures of metabolites, several different kinds of extraction, purification and spectroscopic methods were used (Extrelut LC, TLC, HPLC, MS, NMR, IR, UV and CD). For mass spectral analysis, various ionization techniques (EI, CI and FAB-MS) were performed as complementary methods. After oral administration of [14C]-CEDU to mice and rats, the parent compound, 5-(2chloroethyl) uracil [CEU] and hydroxylated CEU metabolites were isolated and identified from urine and faeces by the above mentioned methods. The CEDU showed rapid phosphorolysis in vitro with thymidine phosphorylase Km 41.0 +/- 5.0; and uridine phosphorylase Km 10.0 +/- 1.5. The cleavage of the N-glycosidic bond of the nucleoside analogue and a new metabolic pathway of CEDU [stereoselective oxidation of 5-(2-chloroethyl) uracil] was observed in both species.

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Section: Discussionmentioning

confidence: 99%

Metabolism of anti-herpes agent 5-(2-chloroethyl)-2′-deoxyuridine in mice and rats

Szlnai

Veres

Ganzler

et al. 1991

European Journal of Drug Metabolism and Pharmacokinetics

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Silicones

Moretto¹,

Schulze²,

Wagner³

2000

Ullmann's Encyclopedia of Industrial Chemistry

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The article contains sections titled: 1. Introduction 2. Linear and Cyclic Polyorganosiloxanes 2.1. Production 2.1.1. Hydrolysis 2.1.2. Methanolysis 2.1.3. Cyclization 2.1.4. Polymerization 2.1.5. Polycondensation 2.1.6. Industrial Production of Linear Polysiloxanes 2.2. Polydimethylsiloxanes 2.3. Siloxane‐Based Copolymers 3. Silicone Fluids 3.1. Methylsilicone Fluids 3.2. Methylphenylsilicone Fluids 3.3. Other Types of Silicone Fluids 3.4. Properties 3.5. Formulation 3.6. Applications 4. Silicone Rubbers and Elastomers 4.1. General Properties 4.2. Rubber Compounds 4.3. Rheology 4.4. Curing Systems 4.4.1. Radical Curing with Peroxides 4.4.2. Hydrosilylation Curing 4.4.3. Condensation Curing 4.4.4. Radiation Curing 4.4.5. Oxidative Coupling 4.5. Peroxide‐Cured High‐Temperature Vulcanizing Silicone Rubbers 4.6. Liquid Silicone Rubbers 4.7. Room Temperature Curing Silicone Rubbers 4.7.1. Two‐Component RTV Systems 4.7.2. One‐Component RTV Systems 4.8. Paper and Textile Coatings 4.8.1. Paper Coating 4.8.2. Textile Coating 4.9. Properties of Silicone Elastomers 4.10. Applications 5. Silicone Resins 5.1. Structure and General Properties 5.2. Production 5.3. Curing 5.4. Properties 5.5. Applications 6. Block and Graft Copolymers 6.1. Polysiloxane ‐ Polyether Copolymers 6.2. Other Block Copolymers 6.3. Graft Copolymers 6.4. Applications of Block and Graft Copolymers 7. Analysis 8. Toxicology 9. Environmental Aspects 10. Economic Aspects

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ChemInform Abstract: Mutagenic and Antimutagenic Effects of 5‐Substituted 2′‐Deoxyuridines Depending on the Nature of the 5‐Substituent.

Cited by 2 publications

References 0 publications

Metabolism of anti-herpes agent 5-(2-chloroethyl)-2′-deoxyuridine in mice and rats

Metabolism of anti-herpes agent 5-(2-chloroethyl)-2′-deoxyuridine in mice and rats

Silicones

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