ChemInform Abstract: N‐Heterocyclic Carbene (NHC) Catalyzed Cycloaddition of CO₂ to N‐Tosyl Aziridines: Regio‐ and Stereoselective Synthesis of Oxazolidine‐2‐ones.

Abstract

An efficient synthesis of di-and trisubstituted oxazolidinones is described by IPrCl-catalyzed carboxylation of N-tosyl aziridines (I) and (V) with carbon dioxide. The reaction proceeds with retention of the configuration of a trans-disubstituted aziridine and is also successfully applied to an enantiopure aziridine (V). -(SEAYAD*, J.; SEAYAD, A. M.; NG, J. K. P.; CHAI, C. L. L.; ChemCatChem 4 (2012) 6, 774-777, http://dx.doi.org/10.1002/cctc.201200080 ; Inst. Chem. Eng. Sci., Singapore 138665, Singapore; Eng.) -Mischke 41-131