ChemInform Abstract: N‐Nitrosation of Secondary Amines with [NO⁺×Crown×H (NO₃)₂^‐].

Abstract

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Catalytic Aerobic N-Nitrosation by Secondary Nitroalkanes in Water: A Tandem Diazotization of Aryl Amines and Azo Coupling

“…N-Nitrosamines make up an important class of compounds with a diverse array of biological activity and also serve as useful synthetic building blocks for nitrogen-containing molecules . While the utilization of strong oxidants has been developed for the N-nitrosation of amines (Scheme a), the traditional N-nitrosation protocols typically rely on the use of NaNO 2 , due to its ready accessibility, in the presence of acids and other promoters . Nevertheless, the use of transnitrosating reagents has been the choice of N-nitrosation method as these organic nitrites are available from commercial sources.…”