ChemInform Abstract: NaBH₄—I₂ Mediated Chemoselective Reduction of γ‐Lactam and Thio‐γ‐lactam in Presence of Gem‐dicarboxylates: An Easy Access to 1,3‐Diaryl Pyrrolidines.

Abstract

1,3-Diaryl Pyrrolidines. -The selective reduction of γ-lactams is studied. Thus, carbonyl and thiocarbonyl groups in (I) and (III) can be chemoselectively reduced to the corresponding pyrrolidines using excess sodium borohydride/iodine; the ester functionalities remain unchanged. -(BARMAN, G.; HALDAR, P.; DUTTA, N.; RAY*, J. K.; J. Heterocycl. Chem. 48 (2011) 2, 463-467, http://dx.doi.org/10.1002/jhet.542 ; Dep. Chem., Indian Inst. Technol., Kharagpur 721 302, India; Eng.) -H. Haber 33-092