ChemInform Abstract: NEW 2‐METHYL‐DIALKYL‐AMMONIUM‐ALKYL‐THIO‐4‐(P‐SUBSTITUTED)‐PHENYL‐3H‐1,5‐BENZODIAZEPINE IODIDES WITH ANTIBACTERIAL ACTIVITY, NOTE 1

Abstract

Dimercapto‐propen‐one (I) reagieren mit o‐Phenylendiamin (II) zu den Benzodiazepinthionen (III), welche mit den Chloriden (IV) alkyliert werden können.

Antimicrobial Activity of Tibezonium (TBZ)

“…Some lH-4-aryl-2,3-dihydro-l ,5-benzodiazepine-2-thiones synthesi zed in our Research Department [1,2] showed considerable antibacterial activities. Among these compounds the 2-methyldiethylamino-ethylthio-4-(p-phenylthio)-phenyl-3H-l,5-benzodiazepine iodide (TBZ), coded Rec 15-0691 (generic name: tibezonium), appeared as one of the most promising substances for the local prevention and treatment of oro pharyngeal infections [3], especially for its activity against some gram positive bacteria which are frequently responsible of the upper respiratory tract infections.…”