ChemInform Abstract: New 4‐[(5‐Arylidene‐2‐arylimino‐4‐oxo‐3‐thiazolidinyl)methyl]benzoic Acids (VII) Active as Protein Tyrosine Phosphatase Inhibitors Endowed with Insulinomimetic Effect on Mouse C2C12 Skeletal Muscle Cells.

Low Molecular Weight Phosphotyrosine Protein Phosphatases as Emerging Targets for the Design of Novel Therapeutic Agents

“…153 Recently, further optimization efforts have led to new 2-arylimino-4-thiazolidinone derivatives active as inhibitors of human LMW-PTP isoform IF1 and PTP1B with appreciable cellular effectiveness. 156 Structurally different LMW-PTP modulators have been discovered among flavonoids and their analogues. When tested against LMW-PTP from bovine kidney, a series of natural flavonoids proved to modulate enzyme activity differently.…”