ChemInform Abstract: New Derivatives of meso‐(Tetra‐4‐pyridyl)porphin and Some of Their Transformations.

Madakyan, V. N.; Kazaryan, R. K.; Khachatryan, M. A.; Stepanyan, Ani; Kurtikyan, T. S.; Ordyan, M. B.

doi:10.1002/chin.198629288

Cited by 1 publication

(2 citation statements)

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“…New cationic porphyrins and metalloporphyrins, which were synthesized in Armenia (over such 100 compounds), 18,19 have a number of significant differences from the other porphyrins. Firstly, it were obtained chemically synthesized compounds, in which in the pyridyl ring the active hydroxyethyl-, butyl-or allyl-peripheral groups are binds in the 3rd or 4th position (Fig.…”

Section: Porphyrins and Metalloporphyrinsmentioning

confidence: 99%

“…We synthesized a series of new cationic porphyrins and metalloporphyrins with various peripheral groups and metals. 18,19 Numerous studies have shown that the spectral and photophysical properties of porphyrin compounds strongly influenced by the polarity of the environment, intra-and intermolecular charge transfer processes, energy, sensitive to the presence and nature of extra ligands, as well as to distortions of flatness macrocycle caused by its interaction with the outer matrix. 20 It is known that photodynamic action occurs mainly via singlet oxygen.…”

Section: Introductionmentioning

confidence: 99%

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Photophysical properties and photodynamic efficiency of cationic porphyrins

Gyulkhandanyan¹,

Ghazaryan

Paronyan³

et al. 2014

SPIE Proceedings

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Photodynamic inactivation of some microorganisms (St. aureus, E.coli) was investigated and their dependence on photo-physical properties of photosensitizers (PS) (cationic porphyrins and metalloporphyrins) was shown. One of the most important criteria for the effectiveness of the PS`s is the quantum yield of singlet oxygen (γ ∆ ). Our investigations were shown that γ ∆ of metalloporphyrins, containing Zn, significantly higher than of metal-free porphyrins (85-97% and 77-79%, respectively). Previousl y experimentally we were found that under the action cationic porphyrins and metalloporphyrins on Gram (+) and Gram (-) microorganisms efficiency of metalloporphyrins Zn-TOEt4PyP and Zn-TBut4PyP in 3-5 times was higher than the metal-free porphyrins. In this study under the action of porphyrins and their Zn-derivatives on microorganism St. aureus such an effect was confirmed. Using the LED with a peak emission of 405 nm and a power density of 70 mW/cm 2 , and irradiation time of microorganisms from 5 to 30 minutes we have found, that at a concentration of 0.1 ug/ml the highest efficiency is observed of metalloporphyrin Zn-TBut3PyP. Upon irradiation of 10 and 15 min his efficiency is 3-5 times higher than the metal-free porphyrin TOEt4PyP, and irradiation for 30 min via Zn-TBut3PyP is practically completely kills microorganisms. These data correlate with the quantum yield of singlet oxygen for photosensitizers. The 30 mindirect sun exposure (power density of 70 mW/cm 2 ) of photosensitizer solutions showed that a significant photobleaching of porphyrins and metalloporphyrins does not occur. Thus, Zn-containing cationic metalloporphyrins are highly efficient photosensitizers for photodynamic inactivation of microorganisms and PDT.

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Section: Porphyrins and Metalloporphyrinsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%