ChemInform Abstract: New Hepatoprotective Saponins, Bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri Radix: Structure‐Requirements for the Cytoprotective Activity in Primary Cultured Rat Hepatocytes.

Matsuda, Hisashi; Murakami, Toshiyuki; Ninomiya, Kiyofumi; Inadzuki, Masahiro; Yoshikawa, Masayuki

doi:10.1002/chin.199752212

ChemInform

1997

DOI: 10.1002/chin.199752212

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ChemInform Abstract: New Hepatoprotective Saponins, Bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri Radix: Structure‐Requirements for the Cytoprotective Activity in Primary Cultured Rat Hepatocytes.

Hisashi Matsuda

Toshiyuki Murakami

Kiyofumi Ninomiya

et al.

Abstract: New Hepatoprotective Saponins, Bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri Radix: Structure-Requirements for the Cytoprotective Activity in Primary Cultured Rat Hepatocytes.-The 11-oxygen function, the 16β-hydroxyl group and the 3-O-diglycoside moiety are found to be essential to exert the cytoprotective activity. -(MATSUDA, H.; MURAKAMI, T.; NINOMIYA, K.; INADZUKI, M.; YOSHIKAWA, M.; Bioorg. Med.

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Protective effects of <i>Hemidesmus indicus</i> var. pubescens root extract on paracetamol induced hepatic damage

Murali¹,

Ashok²,

Madhavan³

2012

Spatula DD

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This study was conducted to study the hepatoprotective property of Hemidesmus indicus (L.) R.Br. roots. METHODS: Hepatoprotective properties of the methanol extract of the roots of H. indicus var. pubescens were evaluated on paracetamol induced hepatotoxicity. Hepatotoxicity was induced in albino Wistar rats by the administration of paracetamol (1g/kg), p.o. for 7 days. Methanol extract of H. indicus var. pubescens roots (MEHI) was administered at the doses 200 and 400 mg/kg/day, p.o. for 7 days. Serum analysis was performed to estimate the levels of SGOT, SGPT, ALP, total proteins, albumin, total bilirubin, total cholesterol, high density lipoprotein and triglycerides. The liver was isolated and homogenized for the estimation of glutathione and malondialdehyde. Histopathology studies were also performed on the liver samples. RESULTS: The toxic effects of paracetamol were significantly controlled in the extract treated groups which was manifested by the restoration of serum biochemical parameters to near normal levels. CONCLUSIONS: From the study it was concluded that roots of H. indicus var. pubescens possess significant hepatoprotective properties.

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Protective effects of <i>Hemidesmus indicus</i> var. pubescens root extract on paracetamol induced hepatic damage

Murali¹,

Ashok²,

Madhavan³

2012

Spatula DD

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show abstract

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ChemInform Abstract: New Hepatoprotective Saponins, Bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri Radix: Structure‐Requirements for the Cytoprotective Activity in Primary Cultured Rat Hepatocytes.

Cited by 1 publication

References 1 publication

Protective effects of <i>Hemidesmus indicus</i> var. pubescens root extract on paracetamol induced hepatic damage

Protective effects of <i>Hemidesmus indicus</i> var. pubescens root extract on paracetamol induced hepatic damage

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ChemInform Abstract: New Hepatoprotective Saponins, Bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri Radix: Structure‐Requirements for the Cytoprotective Activity in Primary Cultured Rat Hepatocytes.

Cited by 1 publication

References 1 publication

Protective effects of &lt;i&gt;Hemidesmus indicus&lt;/i&gt; var. pubescens root extract on paracetamol induced hepatic damage

Protective effects of &lt;i&gt;Hemidesmus indicus&lt;/i&gt; var. pubescens root extract on paracetamol induced hepatic damage

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Protective effects of <i>Hemidesmus indicus</i> var. pubescens root extract on paracetamol induced hepatic damage

Protective effects of <i>Hemidesmus indicus</i> var. pubescens root extract on paracetamol induced hepatic damage