ChemInform Abstract: Nickel(0)/N‐Heterocyclic Carbene‐Catalyzed Asymmetric [2 + 2 + 2] Cycloaddition of Two Enones and an Alkyne: Access to Cyclohexenes with Four Contiguous Stereogenic Centers.

Abstract

Stereogenic Centers. -A diastereoselective access to cyclohexenes bearing four contiguous stereogenic centers through enantioselective [2 + 2 + 2] cycloaddition of two enones and one alkyne is developed. The process is also highly regioselective for unsymmetrical alkynes, but it is sensitive to both steric and electronic influences. -(KUMAR, R.; TOKURA, H.; NISHIMURA, A.; MORI, T.; HOSHIMOTO, Y.; OHASHI, M.; OGOSHI*, S.; Org. Lett. 17 (2015) 24, 6018-6021, http://dx.