ChemInform Abstract: Nickel‐Catalyzed sp³ C—H Bond Activation from Decarboxylative Cross‐Coupling of α,β‐Unsaturated Carboxylic Acids with Amides.

Abstract

Nickel-Catalyzed sp 3 C-H Bond Activation from Decarboxylative Cross--Coupling of ,-Unsaturated Carboxylic Acids with Amides. -The reaction of (I) with N-methylformamide or N-methylacetamide, respectively, yields only trace amounts of the corresponding products. -(ZHANG, J.-X.; WANG, Y.-J.; WANG*, N.-X.; ZHANG, W.; BAI, C.-B.; LI, Y.-H.; WEN, J.-L.; Synlett 25 (2014) 11, 1621-1625, http://dx.

Advances in Decarboxylative Oxidative Coupling Reaction

“…We developed a decarboxylative cross-coupling of cinnamic acids and amides in 2014. 48 With catalyst Ni(OAc) 2 and oxidant TBHP, this method activated the C−H bond adjacent to nitrogen atom and directly functionalized it.…”