ChemInform Abstract: NMR ANALYSES OF MOLECULAR CONFORMATIONS AND CONFORMATIONAL EQUILIBRIUMS WITH THE LANTHANIDE PROBE METHOD

Inagaki, Fuyuhiko; Miyazawa, Takahito

doi:10.1002/chin.198148365

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“…Ah for DY(TTHA)-~ is pseudocontact in origin since Na+ does not covalently bond with the DY(TTHA)-~ moiety (8,9). The addition of DY(TTHA)-~ can give rise to two perturbations in the NMR spectrum, shifts and enhancement of relaxation.…”

Section: Introductionmentioning

confidence: 97%

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Shift reagent enhanced concurrent ²³Na and ¹H magnetic resonance spectroscopic studies of transcellular sodium distribution in the dog brain in vivo

Eleff

McLennan

Hart

et al. 1993

Magnetic Resonance in Med

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The intracellular to extracellular sodium distribution is one of the primary determinants of action potentials necessary for the electrical function of organs such as brain, heart and skeletal muscle. The ability of shift reagent enhanced 23Na MRS to directly measure the intracellular and extracellular sodium distribution in brain is controversial and centers on the relative contributions of bulk magnetic susceptibility and hyperfine interactions to the observed chemical shifts. In this study, infusion of dysprosium (III) triethylenetetraminehexacetate (Dy(TTHA)-3), resulted in a 23Na MRS spectrum of dog brain with two well resolved peaks at 9 and 0.4 ppm. The 9 ppm peak corresponded to the resonance seen in aspirated blood. After disruption of the blood brain barrier, the single peak at 0.4 ppm split into two peaks at 3 and 0 ppm. The ability of Dy(TTHA)-3 enhanced 23Na MRS to follow global changes in brain sodium distribution was tested during cardiac arrest. The expected rapid Na influx into the intracellular space produced a marked decrease in the 3 ppm signal and a parallel increase in the 0 ppm peak. This is consistent with the assignment of the 3 ppm peak as interstitial sodium and the 0 ppm peak as intracellular sodium.

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Section: Introductionmentioning

confidence: 97%

“…Therefore, in the case of a 'H NMR spectrum of water with a DY(TTHA)-~ to H,O molar ratio of only AX shift should be manifest. Whereas, with 23Na NMR and a DY(TTHA)-~ to Na+ ratio of lo-', the spectrum may be affected by both AX and Ah (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Shift reagent enhanced concurrent ²³Na and ¹H magnetic resonance spectroscopic studies of transcellular sodium distribution in the dog brain in vivo

Eleff

McLennan

Hart

et al. 1993

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

ChemInform Abstract: NMR ANALYSES OF MOLECULAR CONFORMATIONS AND CONFORMATIONAL EQUILIBRIUMS WITH THE LANTHANIDE PROBE METHOD

Cited by 1 publication

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Shift reagent enhanced concurrent ²³Na and ¹H magnetic resonance spectroscopic studies of transcellular sodium distribution in the dog brain in vivo

Shift reagent enhanced concurrent ²³Na and ¹H magnetic resonance spectroscopic studies of transcellular sodium distribution in the dog brain in vivo

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ChemInform Abstract: NMR ANALYSES OF MOLECULAR CONFORMATIONS AND CONFORMATIONAL EQUILIBRIUMS WITH THE LANTHANIDE PROBE METHOD

Cited by 1 publication

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Shift reagent enhanced concurrent 23Na and 1H magnetic resonance spectroscopic studies of transcellular sodium distribution in the dog brain in vivo

Shift reagent enhanced concurrent 23Na and 1H magnetic resonance spectroscopic studies of transcellular sodium distribution in the dog brain in vivo

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Shift reagent enhanced concurrent ²³Na and ¹H magnetic resonance spectroscopic studies of transcellular sodium distribution in the dog brain in vivo

Shift reagent enhanced concurrent ²³Na and ¹H magnetic resonance spectroscopic studies of transcellular sodium distribution in the dog brain in vivo