ChemInform Abstract: NO‐NSAIDs: Gastric‐Sparing Nitric Oxide‐Releasable Prodrugs of Non‐Steroidal Antiinflammatory Drugs.

Abstract

Antiinflammatory Drugs. -Design, synthesis and evaluation of novel NO-releasing non-steroidal antiinflammatory prodrugs such as NO-aspirin (Ia) and NO-diclofenac (Ib) are described. Diclofenac analogue (Ib) shows the most promising pharmacokinetic, antiinflammatory and NO-releasing properties. -(SATYAM*, A.; et al.; Bioorg.