ChemInform Abstract: Novel Isomerization Reaction of N,N‐Dimethyl‐α‐(methoxycarbonyl)‐4‐substituted Benzylammonium N‐Methylides.

Abstract

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Synthesis of β-Silyl-α-amino Acid Derivatives by Cu-Catalyzed Regio- and Enantioselective Silylamination of α,β-Unsaturated Esters

“…7 Additionally, the related pericyclic reaction approaches were developed. 8 Despite the aforementioned certain progress, there are still some disadvantages: only the alanine-type products are accessible (Scheme 1a and 1c, top); strong bases such as LDA (Scheme 1b) and high temperature (Scheme 1c, bottom) are inevitable; and tedious NO 2 /N 3 reduction (Schemes 1a and 1b) and attachment/detachment of the aminoquinoline directing group (Q; Scheme 1c, bottom) are necessary. Moreover, the diastereoselectivity is well controlled in several strategies, 4,7 but the catalytic enantiocontrolled process still remains a challenge.…”