ChemInform Abstract: Novel Neurotrophic Phenylbutenoids from Indonesian Ginger Bangle, Zingiber purpureum.

Abstract

Novel Neurotrophic Phenylbutenoids from Indonesian Ginger Bangle, Zingiber purpureum. -Two new curcuminoids (I), and a new phenylbutenoid dimer (II) are isolated from Bangle (Zingiber purpureum). Compounds (I) promote neurite outgrowth of NGF-mediated PC12 cells. In addition, (Ia) accelerates the prevention of A42 aggregation. -(KUBO*, M.; GIMA, M.; BABA, K.; NAKAI, M.; HARADA, K.; SUENAGA, M.; MATSUNAGA, Y.; KATO, E.; HOSODA, S.; FUKUYAMA, Y.; Bioorg. Med. Chem. Lett. 25 (2015) 7, 1586-1591, http://dx.