ChemInform Abstract: Novel Synthesis of Aza‐phthalimidine Hydroxylactams.

Abstract

Fused pyridine derivatives R 0450Novel Synthesis of Aza-phthalimidine Hydroxylactams. -A convenient and mild method for the synthesis of the title compounds involves the substitution reaction of substrates such as (III) with NBS via an unstable intermediate bromide which is rapidly hydrolyzed into the hydroxyl product during the work-up process. A different reaction course is observed in the case of substrate (VI). The yields of (IV) can be improved with NCS/Bz-O-O-Bz. -(FAN, B.; LIU, Z.; TANG, M.; XU, Y.; TANG, X.; MAO*