ChemInform Abstract: Novel Synthesis of Cyclic α‐Amino Acid Esters via Ene Reaction and Ruthenium‐Catalyzed Ring Rearrangement.

Abstract

Novel Synthesis of Cyclic α-Amino Acid Esters via Ene Reaction and Ruthenium-Catalyzed Ring Rearrangement.-Electrophilic imines (I) and methylenecycloalkanes (II) undergo an uncatalyzed ene reaction to yield α-amino esters whose N-allyl derivatives (V) readily undergo ring-openingring-closing metathesis reaction. -(OSIPOV, SERGEY N.; KOBELIKOVA, NATALIA M.; SHCHETNIKOV, GREGORY T.; KOLOMIETS, ALEXEY F.; BRUNEAU, CHRISTIAN; DIXNEUF, PIERRE H.; Synlett (2001) 5, 621-622; Nesmeyanov Inst. Organoelem. Compd., Russ. Acad. Sci., Moscow 117813, Russia; EN)