ChemInform Abstract: OPTICALLY ACTIVE C7‐SYNTHONS FOR LEUKOTRIENES A4

Total Synthesis of Leukotrienes from Butadiene

“…Ϫ [α] D 20 ϭ Ϫ34.0 (c ϭ 1, CH 2 Cl 2 ) {ref. [30] [α] D 20 ϭ Ϫ32.7 (c ϭ 0.75, CHCl 3 )}. (2R,3R)-Epoxy-7-octen-1-ol (15a): Following the same procedure as described for the preparation of compound 15 but using dimethyl (Ϫ)-tartrate instead of dimethyl (ϩ)-tartrate, compound 13 was transformed to compound 15a.…”

“…[29] Tolstikov et al described a different route from (E)-2,7-octadienol. [30] A stereospecific route to (E)-2,7-octadienol from the propargyl alcohol, involving a selective trans reduction with Li in liquid NH 3 , has also been reported. [31] …”