ChemInform Abstract: Organocatalytic Enantioselective Michael Addition of Malonic Acid Half‐Thioesters to β‐Nitroolefins: From Mimicry of Polyketide Synthases to Scalable Synthesis of γ‐Amino Acids.

Abstract

The amide (ALK) efficiently promotes the asymmetric coupling of nitroolefins with the thioester (II) giving adducts of type (III)/(VII) with high enantioselectivity.