ChemInform Abstract: Oxidative Cross‐Coupling of sp³‐ and sp²‐Hybridized C—H Bonds: Vanadium‐Catalyzed Aminomethylation of Imidazo[1,2‐a]pyridines.

Abstract

Oxidative Cross-Coupling of sp 3 -and sp 2 -Hybridized C-H Bonds: Vanadium-Catalyzed Aminomethylation of Imidazo[1,2-a]pyridines. -In addition to the coupling of substituted imidazo[1,2-a]pyridines with N-methylmorpholine oxide, the corresponding coupling of indoles is successfully performed. -(KASWAN, P.; PORTER, A.; PERICHERLA, K.; SIMONE, M.; PETERS, S.; KUMAR*, A.; DEBOEF, B.; Org. Lett. 17 (2015) 21, 5208-5211, http://dx.doi.org/10.

3d Transition Metals for C–H Activation

“…Very recently, Kumar, DeBoef, and co-workers have also reported on a protocol for the oxidative coupling of C(sp 2 )−H and C(sp 3 )−H using VO(acac) 2 as the catalyst. 358 For The direct functionalization of saturated hydrocarbons to valuable products, such as alcohols, ketones, and carboxylic acids, is among the most attractive and challenging task in academic and industrial research. 361 In this context, vanadium complexes are well known to oxidize hydrocarbons in the presence of oxygen and/or peroxides.…”

Catalytic Applications of Vanadium: A Mechanistic Perspective

“…This aminomethylation process was extended to heterocycles such as imidazo[1,2-a]pyridines and indole by DeBoef and coworkers in 2015 (Scheme 54). 316 The authors reported that the same regiochemical outcome is obtained in a conventional Mannich alkylation with morpholine and paraformaldehyde. Additionally, the reaction is unperturbed by the addition of TEMPO as a radical inhibitor.…”