ChemInform Abstract: Palladium‐ and Copper‐Catalyzed Aryl Halide Amination, Etherification and Thioetherification Reactions in the Synthesis of Aromatic Heterocycles

Sadig, Jessie E. R.; Willis, Michael C.

doi:10.1002/chin.201112253

Cited by 2 publications

(2 citation statements)

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“…Transition-metal-catalyzed C(aryl)-N bond formation reaction is an important tool in organic synthesis [29][30][31][32]. Over the past few years, varied synthetic methods have been developed for the N-arylation of heterocycles.…”

Section: Introductionmentioning

confidence: 99%

Copper-Catalyzed N-Arylation of Pyranoquinolinones with Boronic Acids at Room Temperature without Ligand

Gao

Gao²,

Hai-kuan

et al. 2023

Catalysts

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Pyranoquinolinones synthesized from citral were used for Cu-catalyzed N-arylation with a wide range of arylboric acids. The reaction proceeded well with a broad substrate scope, providing a direct way to access highly functional pyranoquinolinone core structure derivatives in yields of up to 80%. Compared to citral, the compounds we obtained have a much better inhibitory effect on HeLa cervical cancer cells, and compound 3p has an IC50 value of 4.6 μM, lower than cisplatin’s 5.9 μM.

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Section: Introductionmentioning

confidence: 99%

Copper-Catalyzed N-Arylation of Pyranoquinolinones with Boronic Acids at Room Temperature without Ligand

Gao

Gao²,

Hai-kuan

et al. 2023

Catalysts

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“…In this plethora of methodologies, different classifications were used, subdividing the data into synthesis of 2-or 3-substituted or 2,3-disubstituted benzofurans [31,32], or into transition-metal-catalyzed [33][34][35][36][37] vs. metal-free approaches, or pointing out the most recent applications of metal catalyzed C-H insertion [38]. We chose to compare the intra-molecular and inter-molecular methodologies used to build selected bonds.…”

Section: Introductionmentioning

confidence: 99%

Last Decade of Unconventional Methodologies for the Synthesis of Substituted Benzofurans

Chiummiento¹,

D’Orsi²,

Funicello³

et al. 2020

Molecules

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This review describes the progress of the last decade on the synthesis of substituted benzofurans, which are useful scaffolds for the synthesis of numerous natural products and pharmaceuticals. In particular, new intramolecular and intermolecular C–C and/or C–O bond-forming processes, with transition-metal catalysis or metal-free are summarized. (1) Introduction. (2) Ring generation via intramolecular cyclization. (2.1) C7a–O bond formation: (route a). (2.2) O–C2 bond formation: (route b). (2.3) C2–C3 bond formation: (route c). (2.4) C3–C3a bond formation: (route d). (3) Ring generation via intermolecular cyclization. (3.1) C7a-O and C3–C3a bond formation (route a + d). (3.2) O–C2 and C2–C3 bond formation: (route b + c). (3.3) O–C2 and C3–C3a bond formation: (route b + d). (4) Benzannulation. (5) Conclusion.

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ChemInform Abstract: Palladium‐ and Copper‐Catalyzed Aryl Halide Amination, Etherification and Thioetherification Reactions in the Synthesis of Aromatic Heterocycles

Abstract: Review: about 150 refs.

Cited by 2 publications

References 0 publications

Copper-Catalyzed N-Arylation of Pyranoquinolinones with Boronic Acids at Room Temperature without Ligand

Copper-Catalyzed N-Arylation of Pyranoquinolinones with Boronic Acids at Room Temperature without Ligand

Last Decade of Unconventional Methodologies for the Synthesis of Substituted Benzofurans

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