ChemInform Abstract: Palladium Catalyzed C‐Arylation of Amino Acid Derived Hydantoins.

Abstract

Palladium Catalyzed C-Arylation of Amino Acid Derived Hydantoins. -Various aryl iodides are suitable reactants under conditions A) to produce the desired 5,5-disubstituted hydantoin structures. The products can be deprotected at both nitrogens [cf. phenytoin (X)] or selectively at one N-position. Alternatively, hydrolysis leads to formation of the parent amino acid [cf.(XI)]. -(FERNANDEZ-NIETO, F.; MAS ROSELLO, J.; LENOIR, S.; HARDY, S.; CLAYDEN*, J.; Org. Lett. 17 (2015) 15, 3838-3841, http://dx.doi.org/10.1021/acs.orglett.5b01803 ; Sch. Chem., Univ. Manchester, Manchester M13 9PL, UK; Eng.) -Lehmann 51-135