ChemInform Abstract: Palladium‐Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N‐Hydroxysuccinimidyl Formate as CO Surrogate.

Abstract

Palladium-Catalyzed Carbonylation of (Hetero)Aryl, Alkenyl and Allyl Halides by Means of N-Hydroxysuccinimidyl Formate as CO Surrogate. -The reaction is successfully applied in the synthesis of precursors of known acetylcholinesterase inhibitors, e. g. (VII), that can be easily and quantitatively converted into the agents by quaternization with methyl triflate. -(BARRE, A.; TINTAS, M.-L.; ALIX, F.; GEMBUS, V.; PAPAMICAEL, C.; LEVACHER*, V.; J. Org. Chem. 80 (2015) 13, 6537-6544, http://dx.doi.org/10.1021/acs.joc.5b01119 ; INSA Rouen, CNRS, Univ. Normandie, F-76821 Mont-Saint-Aignan, Fr.; Eng.) -M. Tismer 45-060