Abstract:The reactivity of pyrrole derivatives for palladium-catalyzed desulfitative arylation is investigated. 1-Methyl-, 1-phenyl-and 1-benzylpyrroles are successfully coupled with a variety of benzenesulfonyl chlorides using a phosphine-free catalyst. Highly regioselective arylations at carbon C2 of pyrroles are observed in all cases with exception of indoles. A wide variety of substituents on the benzenesulfonyl derivative is tolerated. Even bromoand iodo-benzenesulfonyl chlorides are successfully coupled with pyrr… Show more
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