ChemInform Abstract: Palladium‐Catalyzed Markovnikov‐Selective Hydroselenation of N‐Vinyl Lactams with Selenols Affording N,Se‐Acetals.

Enantioselective Selenol-ene Using Rh-Hydride Catalysis

“…9 Selenols are known to readily add into Michael acceptors, including α,β-unsaturated ketones, 10 a vinylsulfonamide, 11 nitroalkenes, 12 and N-vinyl lactams. 13 There has also been difunctionalization of alkenes to form selenides emerging; however, enantioselective variants of this approach remain unknown. 14 In 2020, Wang and co-workers demonstrated that heterobicyclic alkenes can undergo a formal hydroselenation by combining diselenides and phosphine oxide under asymmetric Rh-catalysis (Figure 1C).…”