ChemInform Abstract: Palladium‐Catalyzed Substitution and Cross‐Coupling of Benzylic Fluorides.

Abstract

Palladium-Catalyzed Substitution and Cross-Coupling of BenzylicFluorides. -A variety of benzyl fluorides is applied in the reactions using carbon, nitrogen, oxygen or sulfur nucleophiles. The process tolerates even halogens on the aromatic ring. Cross-coupling of (IXa) with phenyl boronic acid proceeds chemoselectively depending on the conditions. Chiral (XVI) reacts with some erosion of the optical purity. -(BLESSLEY, G.; HOLDEN, P.; WALKER, M.; BROWN*, J. M.; GOUVERNEUR, V.; Org. Lett. 14 (2012) 11, 2754-2757, http://dx.doi.org/10.1021/ol300977f ; Chem. Res. Lab., Univ. Oxford, Oxford OX1 3TA, UK; Eng.) -R. Steudel 40-025