ChemInform Abstract: Palladium‐Catalyzed Synthesis of Aryl Amides Through Silanoate‐Mediated Hydrolysis of Nitriles.

Abstract

Palladium-Catalyzed Synthesis of Aryl Amides Through Silanoate-Mediated Hydrolysis of Nitriles. -The starting amide salts are prepared by reaction of appropriate nitriles with Tms-OK according to a known procedure. -(MCPHERSON, C. G.; LIVINGSTONE, K.; JAMIESON*, C.; SIMPSON, I.; Synlett 27 (2016) 01, 88-92, http://dx.

Recent Progress in the Synthesis of Drugs and Bioactive Molecules Incorporating Nitro(het)arene Core

“…The key step of the proposed synthesis was the iodination of the corresponding aryl bromide using metal complex catalysis [39] (Scheme 8). General methods for the synthesis of structurally close arylamides using metal complex catalysis have been described recently [34,35]. According to the proposed methods, it is possible to synthesize 3-trifluoroisobutyranilide, a key intermediate in the synthesis of flutamide, in high yields.…”