ChemInform Abstract: Palladium‐Free Zinc‐Mediated Hydroamination of Alkynes: Efficient Synthesis of Indoles from 2‐Alkynylaniline Derivatives.

Abstract

Indole derivatives R 0140Palladium-Free Zinc-Mediated Hydroamination of Alkynes: Efficient Synthesis of Indoles from 2-Alkynylaniline Derivatives. -The N-protected substrates (I) react in the presence of excess ZnBr2 to give 2-substituted indoles (II). In contrast, the unproteced analogues (III) react in the presence of catalytic amounts of zinc halides. -(OKUMA*, K.; SETO, J.-I.; SAKAGUCHI, K.-I.; OZAKI, S.; NAGAHORA, N.; SHIOJI, K.; Tetrahedron Lett. 50 (2009) 24, 2943-2945; Dep. Chem., Fac. Sci.,