ChemInform Abstract: Phenylboronic Acid as Efficient and Eco‐Friendly Catalyst for the One‐Pot, Three‐Component Synthesis of α‐Aminophosphonates under Solvent‐Free Conditions.

Abstract

Aliphatic and aromatic aldehydes react with benzylamine and dimethyl phosphite within a short time to give the title compounds in good to excellent yields.

Relationship between Structure and Antibacterial Activity of α-Aminophosphonate Derivatives Obtained via Lipase-Catalyzed Kabachnik−Fields Reaction

“…All microorganisms and media were accurately described in detail in the previous work [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ] and analyzed by a Tukey test.…”

“…The bovine acetone powder was prepared in our laboratory according to the literature procedure [ 38 ]. Symmetrical and unsymmetrical H -phosphites were obtained via alcoholysis of the dimethyl phosphite with the appropriate alcohol according to the literature procedure [ 40 , 41 , 42 , 43 , 44 , 45 , 46 ] (see Supplementary Materials ).…”

Recent Advances in H-Phosphonate Chemistry. Part 2. Synthesis of C-Phosphonate Derivatives

“…Heterogeneous catalysts based on irondoped single walled carbon nanotubes showed similar efficiency and usability [36]. Simple inorganic salts (CaCl 2 [37] and KHSO 4 [38]), phosphorofluoridic acid [39], and phenylboronic acid [40] have been advocated as superior, cheap catalysts for the Kabachnik-Fields reaction under solvent-free conditions. Tosyl chloride was also proposed as a catalyst for this reaction because of its ability to stabilize more nucleophilic, tervalent phosphite forms of H-phosphonates [41].…”