ChemInform Abstract: PHOTOSENSITIZED OXYGENATION OF ABIETA‐7,9(11)‐DIEN‐13β‐OL

Abstract

Durch Dehydratisierung entsteht aus dem Diol (I) ein trennbares Gemisch aus der Titelverbindung (II) und dem Trien (III).

Labdane-Type Diterpenes Active against Acne from Pine Cones (Pinus densiflora)

“…The specific rotation for a C-4 epimer, 15-nor-14-oxolabda-8( 17),12E-diene-19-oic acid, was reported as + 39.5 (c 0.15, CHCl 3 ) [9] and + 40 (c 0.18) [8]. The structures of the other isolates were characterized by comparison of their respective spectral data with those reported in the literature: 8(17),12,14-labdan-trien-18-oic acid (4-epi-communic acid) (2) [13], 15-hydroxydehydroabietic acid (3) [11], dehydroabietic acid (4) [14], 18-norabieta-8,11,13-trien-4-ol (5) [15], dehydroabietinol (6) [16], 18-hydroxyabieta-8,11,13-trien-7-one (7) [17], dehydroabietic acid-7-one (8) [18], and abieta-8,11,13-trien-7-ol (9) [19]. Compounds 1 -9 were tested against anaerobic Gram-positive bacteria, P. acnes and Streptococcus mutans, aerobic Gram-positive bacteria, Bacillus subtilis, Staphylococcus aureus, Gram-negative bacteria, Shigella sonnei, Pseudomonas aeruginosa, Escherichia coli, and fungi, Candida kruisii, Candida glabrata, Trichophyton mentagrophytes.…”