ChemInform Abstract: POTENTIAL CENTRAL NERVOUS SYSTEM ANTITUMOR AGENTS. AZIRIDINYLBENZOQUINONES. 2

Quinone-containing alkylating agents are a class of chemical agents that have received considerable interest as anticancer drugs. These agents contain a quinone moiety that can be reduced and an alkylating group that can form covalent bonds with a variety of cellular components. The oxidation state of the quinone element can modulate the activity of the alkylating element, and reduction of the quinone is required for activation of the alkylating activity of many of these agents. The quinone element may also contribute to the cytotoxic activity of quinone-containing alkylating agents through the formation of reactive oxygen species during redox cycling.The natural product, mitomycin C, has been the most widely used quinonecontaining alkylating agent in the clinic, but other quinonecontaining alkylating agents like porfiromycin, diaziquone, carbazilquinone, triaziquone and EO9 havealso been used in the clinic for the treatment of cancer. In addition, many other quinone-containing alkylating agents have been tested

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ChemInform Abstract: POTENTIAL CENTRAL NERVOUS SYSTEM ANTITUMOR AGENTS. AZIRIDINYLBENZOQUINONES. 2

Abstract: Zu Untersuchungen auf tumorhemmende Wirkung werden aus den Tetrahalogenchinonen (I), z.B. über Zwischenstufen (II), die Aziridine (III) in der üblichen Weise hergestellt.

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Mechanisms of action of quinone-containing alkylating agents i: NQO1-directed drug development

Mechanisms of action of quinone-containing alkylating agents i: NQO1-directed drug development

Clinical applications of quinone-containing alkylating agents

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