ChemInform Abstract: Practical Cleavage of Trifluoroacetamides with p‐Toluenesulfonic Acid.

Abstract

Deprotection O 0345Practical Cleavage of Trifluoroacetamides with p-Toluenesulfonic Acid. -The protocol allows the deprotection of secondary and tertiary trifluoroacetamides. The corresponding amines are obtained as tosylate salts which can be isolated directly from the reaction mixture. -(SPENCER, C.; BALSELLS, J.; LI*, H.; Tetrahedron Lett. 50 (2009) 9, 1010-1012; Dep. Process Res., Merck & Co., Inc., Rahway, NJ 07065, USA; Eng.) -Mais 23-057