ChemInform Abstract: Practical Synthesis of Phenanthridinones by Palladium‐Catalyzed One‐Pot C—C and C—N Coupling Reaction: Extending the Substrate Scope to o‐Chlorobenzamides.

Liu, Hailong; Han, Weibiao; Li, Chun; Ma, Zhiyong; Li, Ruixiang; Zheng, Xueli; Fu, Haiyan; Chen, Hua

doi:10.1002/chin.201622159

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Simultaneous Aryl–aryl and N –Aryl Coupling Reactions For Phenanthridinone Synthesis1

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2021

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“…2-Bromobenzamides 7 could be subjected to Pd-catalyzed homocoupling, delivering phenanthridinone derivatives 8 [ 70 , 71 , 72 ] ( Scheme 4 ). In 2016, phenanthridinone synthesis was realized starting from o -halobenzamides under phosphine-free palladium catalysis in N , N -dimethylacetamide [ 73 ]. Authors also demonstrated this methodology in a scalable process by performing gram scale reactions.…”

Section: Simultaneous Aryl–aryl and N –Aryl Coupling Reactions For Phenanthridinone Synthesismentioning

confidence: 99%

Synthetic Strategies in the Preparation of Phenanthridinones

et al. 2021

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Phenanthridinones are important heterocyclic frameworks present in a variety of complex natural products, pharmaceuticals and displaying wide range of pharmacological actions. Its structural importance has evoked a great deal of interest in the domains of organic synthesis and medicinal chemistry to develop new synthetic methodologies, as well as novel compounds of pharmaceutical interest. This review focuses on the synthesis of phenanthridinone scaffolds by employing aryl-aryl, N-aryl, and biaryl coupling reactions, decarboxylative amidations, and photocatalyzed reactions.

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